Dimethyl Sulfoxide
Chemscene ChemScene | Dimethyl sulfoxide, meets analytical specification of Ch.P. | 220G | CS-B1637 | 0.999 | 67-68-5| MFCD00002089 | 78.13
ChemScene | Dimethyl sulfoxide, meets analytical specification of Ch.P. | 220G | CS-B1637 | 0.999 | 67-68-5| MFCD00002089 | 78.13
Apexbio Technology LLC Atglistatin 1469924-27-3 10mM (in 1mL DMSO)
Atglistatin (CAS 1469924-27-3) is a small-molecule inhibitor selective for adipose triglyceride lipase (ATGL) an enzyme that catalyzes the rate-limiting step in triglyceride hydrolysis releasing fatty acids from cellular triglyceride stores Atglistatin inhibits ATGL activity competitively with an IC50 of 0 7 M and Ki of 355 nM In mouse white adipose tissue lysates atglistatin decreased triglyceride hydrolase activity by approximately 78% effectively reducing fatty acid and glycerol release This compound serves as a valuable tool in lipid metabolism and metabolic disease research
Apexbio Technology LLC Febuxostat 144060-53-7 10mM (in 1mL DMSO)
Febuxostat (CAS 144060-53-7) is a non-purine selective inhibitor of xanthine oxidase (XO) an enzyme involved in purine metabolism responsible for producing uric acid and reactive oxygen species (ROS) It exerts its inhibitory action by noncompetitive binding at the molybdenum-pterin active center of XO effectively inhibiting both its oxidized and reduced forms Compared to allopurinol febuxostat demonstrates notably higher potency with a reported IC50 of 1 8 nM versus 2 9 M Febuxostat is utilized in clinical and preclinical research exploring hyperuricemia gout and associated metabolic disorders
Apexbio Technology LLC Meropenem 96036-03-2 10mM (in 1mL DMSO)
Meropenem is a broad-spectrum -lactam antibiotic within the carbapenem subclass characterized by bactericidal activity against both gram-positive and gram-negative organisms It primarily acts by binding to penicillin-binding proteins (PBPs) mainly PBP2 of Escherichia coli and Pseudomonas aeruginosa and PBP1 of Staphylococcus aureus thus disrupting cell wall synthesis and bacterial growth In vitro studies indicate Meropenem inhibition is effective at MIC 4 mg/L (susceptible strains) intermediate at 8 mg/L and resistant at 16 mg/L Meropenem demonstrates greater potency against gram-negative bacteria compared to Imipenem with typical IC50 values around 0 25 mg/L for anaerobic strains It is typically used in microbiological research to investigate antibiotic susceptibility bacterial resistance mechanisms and interactions with drug metabolism
Apexbio Technology LLC Lovastatin 75330-75-5 10mM (in 1mL DMSO)
Lovastatin (CAS 75330-75-5) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) a rate-controlling enzyme in cholesterol biosynthesis that mediates conversion of HMG-CoA to mevalonate In vitro assays show that lovastatin inhibits HMG-CoA reductase activity with IC50 values of 2 3 nmol/L in rat hepatocytes and 5 nmol/L in human hepatoma HepG2 cells By decreasing mevalonate and subsequent isoprenoid intermediates lovastatin reduces cellular proliferation and DNA synthesis It also enhances macrophage-mediated clearance of apoptotic cells at concentrations around 5 M Lovastatin serves as a useful tool in studies investigating lipid metabolism cellular proliferation pathways and related inflammatory processes
Apexbio Technology LLC Afatinib (BIBW2992) 439081-18-2 10mM (in 1mL DMSO)
Afatinib (BIBW2992 CAS 439081-18-2) is an irreversible inhibitor targeting receptor tyrosine kinases in the ErbB protein family specifically EGFR (ErbB1) and HER2 (ErbB2) By covalently binding to their kinase domains it suppresses downstream ErbB signaling showing demonstrated inhibition with IC50 values of 0 5 nM for EGFR and 14 nM for HER2 Afatinib blocks EGF-induced phosphorylation and cellular proliferation in multiple EGFR- or HER2-expressing lines including A431 NIH-3T3-HER2 NCI-N87 and BT-474 Research applications include tumor xenograft studies and transgenic lung cancer models evaluating EGFR-dependent oncogenic processes and therapeutic responses
Apexbio Technology LLC ZM 447439 331771-20-1 10mM (in 1mL DMSO)
ZM 447439 (CAS 331771-20-1) is a selective inhibitor of Aurora kinases a subgroup within the serine/threonine kinase family involved in chromosome segregation during cell division It inhibits recombinant Aurora A and Aurora B kinases with IC50 values of approximately 110 nM and 130 nM respectively consequently reducing phosphorylation of histone H3 at serine 10 ZM 447439 demonstrates limited inhibitory activity towards other kinases with IC50 values above 10 M for CDK1/2/4 IKK1/2 PLK1 CHK1 cFLT2 KDR2 FAK and Zap-70 In biological research ZM 447439 is commonly employed to study mitotic regulation chromosomal alignment and apoptosis signaling pathways
Apexbio Technology LLC ABT-199 1257044-40-8 10mM (in 1mL DMSO)
ABT-199 (CAS 1257044-40-8) is a selective small-molecule inhibitor targeting BCL-2 developed through structure-guided drug design By specifically interfering with the mitochondrial apoptotic pathway regulated by BCL-2 ABT-199 induces apoptosis predominately in cells dependent on BCL-2 signaling rather than BCL-XL In preclinical assessments ABT-199 exhibited antitumor activity against hematologic malignancies including BCL-2-dependent non-Hodgkin lymphoma (NHL) and acute myeloid leukemia (AML) cell lines and xenograft models while demonstrating minimal platelet toxicity
Apexbio Technology LLC Cinobufagin 470-37-1 10mM (in 1mL DMSO)
Cinobufagin (CAS 470-37-1) is a steroidal cardiac glycoside recognized for its inhibitory effect on the Na /K -ATPase pump Its inhibitory potency is approximately comparable to that of ouabain By impeding Na /K -ATPase activity cinobufagin disrupts ionic gradients altering intracellular calcium homeostasis and influencing cardiac and cellular functions In biomedical research cinobufagin serves as a valuable pharmacological tool to investigate ion transport mechanisms and explore related signaling pathways implicated in cellular physiology and pathology
Selleck Chemical LLC Trametinib DMSO solvate S4484-1g
Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0 92 nM/1 8 nM in cell-free assay Trametinib activates autophagy and induces apoptosis
Selleck Chemical LLC Trametinib DMSO solvate S4484-25mg
Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0 92 nM/1 8 nM in cell-free assay Trametinib activates autophagy and induces apoptosis
Medchemexpress LLC Pemigatinib | 1513857-77-6 | 487.5 g/mol | 1ML
Pemigatinib | 1513857-77-6 | 487.5 g/mol | 1ML
